Computer-directed assembly of a polynucleotide encoding a target polypeptide
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United States of America Patent
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Jun 21, 2011
Grant Date -
Mar 8, 2007
app pub date -
Oct 20, 2004
filing date -
Jan 19, 2001
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Abstract
The present invention outlines a novel approach to utilizing the results of genomic sequence information by computer-directed polynucleotide assembly based upon information available in databases such as the human genome database. Specifically, the present invention may be used to select, synthesize and assemble a novel, synthetic target polynucleotide sequence encoding a target polypeptide. The target polynucleotide may encode a target polypeptide that exhibits enhanced or altered biological activity as compared to a model polypeptide encoded by a natural (wild-type) or model polynucleotide sequence.
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