Conjugates and compositions for cellular delivery
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United States of America Patent
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Jun 21, 2011
Grant Date -
Oct 22, 2009
app pub date -
Oct 16, 2008
filing date -
May 18, 2001
priority date (Note) -
Expired
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Abstract
This invention features conjugates, degradable linkers, compositions, methods of synthesis, and applications thereof, including cholesterol, folate, galactose, galactosamine, N-acetyl galactosamine, PEG, phospholipid, peptide and human serum albumin (HSA) derived conjugates of biologically active compounds, including antibodies, antivirals, chemotherapeutics, peptides, proteins, hormones, nucleosides, nucleotides, non-nucleosides, and nucleic acids including enzymatic nucleic acids, DNAzymes, allozymes, antisense, dsRNA, siNA, siRNA, triplex oligonucleotides, 2,5-A chimeras, decoys and aptamers.
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