siRNA microbicides for preventing and treating diseases
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United States of America Patent
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May 17, 2011
Grant Date -
Jan 22, 2009
app pub date -
Jun 5, 2006
filing date -
Jun 3, 2005
priority date (Note) -
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Abstract
The invention provides a microbicidal composition comprising at least one siRNA. The siRNA is an RNA duplex made of one or two molecules. A portion of the siRNA is identical to a target sequence in an essential gene of a virus. The virus may be a herpesvirus, for example, HSV-1 or HSV-2. Preferably, the herpesvirus is HSV-2. The microbicidal composition further comprises a pharmaceutically acceptable carrier. Also included in the invention are methods to prevent and treat viral infections by administration of the microbicidal composition. Preferably, the microbicidal composition is administered transmucosally.
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