Methods of generating a humoral immune response against human immunodeficiency virus (HIV) comprising administering Nef apoptotic motif-containing polypeptide-conjugates
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United States of America Patent
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May 17, 2011
Grant Date -
Aug 18, 2005
app pub date -
Jan 7, 2005
filing date -
Jan 9, 2004
priority date (Note) -
Expired
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Abstract
A small peptide of 10 or 11 mers, when linked to an immunogenic moiety, can protect against naferious effects of Nef protein of HIV. The vaccine is not used to induce sterilizing immunity, but to block the ability of soluble Nef protein to induce apoptosis, and to therefore alleviate lymphocyte depletion and organ damage.
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