Aerosolized fosfomycin/aminoglycoside combination for the treatment of bacterial respiratory infections

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United States of America Patent

PATENT NO 7943118
APP PUB NO 20070218013A1
SERIAL NO

11596566

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Abstract

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A fosfomycin plus tobramycin combination formulation for delivery by aerosolization is described. The concentrated fosfomycin tobramycin combination formulation containing an efficacious amount of fosfomycin plus tobramycin is able to inhibit susceptible bacteria. Fosfomycin and tobramycin are formulated separately in a dual ampoule such that when reconstituted, the pH is between 4.5 and 8.0 or as a dry powder. The method for treatment of respiratory tract infections by a formulation delivered as an aerosol having a mass median aerodynamic diameter predominantly between 1 to 5μ, produced by a jet or ultrasonic nebulizer (or equivalent) or dry powder inhaler.

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Patent Owner(s)

Patent OwnerAddress
GILEAD SCIENCES INC333 LAKESIDE DRIVE FOSTER CITY CA 94404

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Baker, William Bellevue, US 54 1087
MacLeod, David Issaquah, US 21 746

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