Process for preparing a sterile high molecular weight hyaluronic acid formulation
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United States of America Patent
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May 10, 2011
Grant Date -
Mar 9, 2006
app pub date -
Aug 4, 2003
filing date -
Aug 7, 2002
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Abstract
A process for preparing a sterile ready-to-use aqueous pharmaceutical formulation comprises a high molecular weight hyaluronic acid salt (HA) at a specified concentration, comprising the steps of: providing an aqueous formulation comprising high molecular weight HA at a concentration of less than the specified final concentration; passing said aqueous formulation through a filter having a pore sizeless than 0.45 pm; concentrating said aqueous formulation by applying a vacuum and boiling off water until said specified concentration is reached.
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