Multistep process for the physical depolymerization of heparin and products obtained therefrom
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United States of America Patent
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May 10, 2011
Grant Date -
Apr 12, 2007
app pub date -
Apr 13, 2006
filing date -
Oct 13, 2004
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Abstract
The present invention is directed to a multistep process for the physical depolymerization of heparin wherein heparin is subjected to at least two γ-ray irradiations and wherein between two irradiation steps the depolymerised heparin is subjected to a separation step and only a fraction of the depolymerised heparin obtained from the first irradiation is subjected to the second irradiation step. It is also directed to heparin-derived oligosaccharide fractions obtainable by the process of the invention.
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