Rapid thermocycler with movable cooling assembly
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United States of America Patent
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May 10, 2011
Grant Date -
Mar 6, 2008
app pub date -
Apr 9, 2007
filing date -
Aug 30, 2006
priority date (Note) -
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Abstract
Methods and apparatus for effecting rapid thermocycling in connection with the polymerase chain reaction are disclosed. A sample assembly having a relatively small thermal mass is heated to desired PCR operating temperatures, and a separate cooling assembly is used to rapidly lower the temperature as required. In one embodiment, a sample assembly with an integrated heating element is isolated from a relatively large thermal mass cold sink when the temperature of a sample is to be raised or maintained, and brought in contact with the cold sink when the temperature is desired to be lowered.
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