Trp/his exchange and kynurenine induced Trp transport
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United States of America Patent
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May 3, 2011
Grant Date -
Sep 18, 2008
app pub date -
Feb 29, 2008
filing date -
Mar 1, 2007
priority date (Note) -
Expired
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Abstract
The present invention provides methods for detecting changes in tryptophan concentrations in a cell and methods for identifying agents that modulate cellular tryptophan concentrations. In particular, the present invention provides methods for detecting cellular exchange between tryptophan and kynurenine, and methods for identifying agents that modulate this exchange. The present invention also provides methods for treating a disease associated with immunosuppression in a subject in need thereof. In particular, the present invention is directed toward a method of treating a disease associated with immunosuppression comprising contacting the disease with an agent that modulates cellular Trp/kynurenine exchange. Furthermore, the present invention provides methods for identifying an agent that modulates an immunosuppression.
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