dUTP-based compositions for reducing primer-aggregate formations during nucleic acid amplification
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United States of America Patent
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Apr 26, 2011
Grant Date -
Nov 15, 2007
app pub date -
Feb 4, 2005
filing date -
Feb 4, 2004
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Abstract
Methods and compositions are provided for enhanced specificity and sensitivity of amplification reaction mixtures. Compositions in accordance with the present invention provide for reduced formation of primer-aggregates during amplification reactions. Reaction mixes include dNTPs, where a portion of the dNTPs has been replaced with an unconventional nucleotide, e.g., dUTP. Unconventional nucleotide concentrations are typically between 10% to 50% of the concentration of one of the standard dNTP. In some compositions the unconventional nucleotide is dUTP which replaces from about 10% to about 50% of the dTTP in the dNTP mix.
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