Soluble heterodimeric CD94/NKG2 receptors fusion proteins
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United States of America Patent
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Apr 26, 2011
Grant Date -
Nov 12, 2009
app pub date -
Jun 22, 2007
filing date -
Jun 22, 2006
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Abstract
Soluble versions of heterodimeric receptors, e.g., CD94/NKG2 receptors, and methods of producing and using such constructs, are described. The constructs comprise soluble fragments of, each receptor monomer, and some constructs further comprise at least one immunoglobulin Fc domain. Exemplary constructs are those wherein (1) each soluble fragment is linked to an immunoglobulin Fc domain, which are then allowed to dimerize, (2) each soluble fragment is linked to an immunoglobulin Fc domain mutated to promote forced dimerization with the correct counterpart, and (3) single-chain constructs where the monomeric receptor fragments are linked, and the C-terminal fragment is linked to an Fc domain.
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