Method for preparing modified collagen outside a host cell
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United States of America Patent
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Apr 26, 2011
Grant Date -
Apr 10, 2008
app pub date -
Apr 7, 2005
filing date -
Apr 8, 2004
priority date (Note) -
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Abstract
The present invention relates to a method for preparing a modified folded protein, comprising modifying unfolded a-chains comprising a collagenous amino acid sequence and thereafter folding at least part of the modified a-chains into a quaternary protein structure, in particular a helical protein structure. The invention allows for an attractive alternative for making recombinant proteins, such as recombinant collagens and the like, which may be used in a variety of biomedical and other applications.
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