Process for preparation of substituted sulfoxides
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United States of America Patent
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Apr 19, 2011
Grant Date -
Jun 7, 2007
app pub date -
Jan 8, 2007
filing date -
Apr 28, 2004
priority date (Note) -
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Abstract
The present invention relates to a process for preparing substituted sulfoxides either as a single enantiomer or in an enantiomerically enriched form. Thus, racemic omeprazole is reacted with (S)-camphorsulfonyl chloride to form a diastereomeric mixture and the diastereomers are separated by fractional crystallization, followed by deprotection to give esomeprazole.
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