Nucleic acids encoding P-selectin ligand fusion proteins
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United States of America Patent
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Apr 19, 2011
Grant Date -
Nov 13, 2008
app pub date -
Jul 3, 2008
filing date -
Oct 23, 1992
priority date (Note) -
Expired
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Abstract
A novel P-selectin ligand glycoprotein is disclosed, comprising the amino acid sequence set forth in SEQ ID NO:2 or by the amino acid sequence set forth in SEQ ID NO:4. DNA sequences encoding the P-selectin ligand protein are also disclosed, along with vectors, host cells, and methods of making the P-selectin ligand protein. Pharmaceutical compositions containing the P-selectin ligand protein and methods of treating inflammatory disease states characterized by P-selectin- and E-selectin-mediated intercellular adhesion are also disclosed.
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