Tandem analyses of noncovalently driven effectors for modulatory mapping of activities of protein sites
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United States of America Patent
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Apr 19, 2011
Grant Date -
Sep 9, 2004
app pub date -
Jan 16, 2004
filing date -
Jan 17, 2003
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Abstract
The present invention provides methods of discovering and mapping secondary binding sites on biological molecules (e.g., proteins), the effects, if any, of site occupancy on the primary function of the molecule, and the screening of small molecules against the secondary binding sites. The invention further provides novel complexes for modification of secondary binding sites and the resulting modified biological molecules.
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