Use of C5a receptor antagonist in the treatment of fibrosis

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United States of America Patent

PATENT NO 7919459
APP PUB NO 20080058252A1
SERIAL NO

11807651

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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This invention relates to the use of an antagonist of a G protein-coupled receptor in the prevention and/or treatment of fibrosis, such as the treatment of fibrosis associated with myocardial infarction or diabetes or certain pulmonary conditions. In a preferred embodiment, the antagonist is a C5a receptor antagonist, more preferably a cyclic peptide antagonist of the C5a receptor. In particular, the invention provides a method of prevention, treatment or alleviation of a fibrotic condition, comprising the step of administering an effective amount of an antagonist of a G protein-coupled receptor to a subject in need of such treatment.

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Patent Owner(s)

Patent OwnerAddress
PROMICS PTY LIMITEDNEW SOUTH WALES

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Brown, Lindsay Charles Sinnamon Park, AU 4 33
Shiels, Ian Alexander Muirlea, AU 9 12
Taylor, Stephen Maxwell Bellbird Park, AU 17 50
Whitehouse, Michael Wellesley Holland Park, AU 4 14

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