Use of C5a receptor antagonist in the treatment of fibrosis
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United States of America Patent
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Apr 5, 2011
Grant Date -
Mar 6, 2008
app pub date -
May 30, 2007
filing date -
Apr 8, 2002
priority date (Note) -
Expired
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Abstract
This invention relates to the use of an antagonist of a G protein-coupled receptor in the prevention and/or treatment of fibrosis, such as the treatment of fibrosis associated with myocardial infarction or diabetes or certain pulmonary conditions. In a preferred embodiment, the antagonist is a C5a receptor antagonist, more preferably a cyclic peptide antagonist of the C5a receptor. In particular, the invention provides a method of prevention, treatment or alleviation of a fibrotic condition, comprising the step of administering an effective amount of an antagonist of a G protein-coupled receptor to a subject in need of such treatment.
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