Motif of the beclin protein which interacts with anti-apoptotic members of the Bcl-2 protein family, and uses
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United States of America Patent
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Apr 5, 2011
Grant Date -
Apr 16, 2009
app pub date -
Jan 31, 2006
filing date -
Feb 1, 2005
priority date (Note) -
Expired
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Abstract
The invention relates to a method of identifying modulators of programmed cell death, comprising an interaction between a motif of Beclin protein and an anti-apoptotic member of the family of Bcl-2 proteins and the detection of said interaction be means of fluorescence polarization. The modulators identified on the basis of said method are administered to cancer patients in order to induce apoptotic- and/or autophagic-type programmed cell death. The invention also relates to a motif of the Beclin protein which can interact with an anti-apoptic member of the family of Bcl-2 proteins and to the use thereof in order to induce programmed cell death in a cancer patient.
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