Spectroscopic determination of enantiomeric purity
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United States of America Patent
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Mar 22, 2011
Grant Date -
Dec 10, 2009
app pub date -
Sep 30, 2005
filing date -
Oct 1, 2004
priority date (Note) -
Expired
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Abstract
A new method and strategy for the quantitative determination of enantiomeric purity that combines polarimetry, spectroscopy, and chemometric modeling. Spectral data is collected after a light beam is passed through a first polarimeter, a sample of a chiral compound, and a second polarimeter oriented at a 45 degree angle relative to the first polarimeter. The spectral data for samples of known enantiomeric composition is subjected to a type of multivariate regression modeling known as partial least squares (“PLS-1”) regression. The PLS-1 regression produces a mathematical model that can be used to predict the enantiomeric composition of a set of samples of unknown enantiomeric purity.
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