Stem cell expansion and uses
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United States of America Patent
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Mar 22, 2011
Grant Date -
Apr 5, 2007
app pub date -
Mar 25, 2006
filing date -
Sep 29, 2004
priority date (Note) -
Expired
status (Latency Note)
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Abstract
The invention relates to methods to prevent, treat, ameliorate or slow the progression of one or more of a blood cell deficiency, unwanted inflammation, allergy, immune suppression condition, immunosenescence, autoimmune disorder, infection, neurological disorder, cardiovascular disorder, pulmonary disorder, trauma, hemorrhage, bone fracture or unwanted or excess bone loss with steroid compounds containing carbon-carbon double bonds within the fused four-ring system such that the steroid compounds are unsaturated. The unsaturated steroid compounds include 3,16α,17β-trihydroxy-7-acetoxy-androst-1,3,5(10),6-tetraene, 3,16α,17β-trihydroxy-7-methoxy-androst-1,3,5(10),6-tetraene, 3,17β-dihydroxy-7-acetoxy-16α-fluoro-androst-1,3,5(10),6-tetraene, 3,17β-dihydroxy-7-methoxy-16α-fluoro-androst-1,3,5(10),6-tetraene, 3,17β-dihydroxy-7,16α-diacetoxy-androst-1,3,5(10),6-tetraene and 3,17β-dihydroxy-7-methoxy-16α-acetoxy-androst-1,3,5(10),6-tetraene.
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