Process for the preparation of delmopinol and derivatives thereof

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United States of America Patent

PATENT NO 7910730
APP PUB NO 20100222579A1
SERIAL NO

12779288

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Abstract

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A process for the preparation of delmopinol (3-(4-propylheptyl)-4-morpholinethanol) or a derivative or a pharmaceutically acceptable salt, or a solvate thereof, including a hydrate, comprises reacting oxazolidin [2,3-c] morpholine and a Grignard reagent, and optionally converting the delmopinol (or derivative) free base into a pharmaceutically acceptable salt. The oxazolidin [2,3-c] morpholine and the Grignard reagent are useful as intermediates in the production process.

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Patent Owner(s)

Patent OwnerAddress
SINCLAIR PHARMACEUTICALS LIMITEDGODALMING SURREY GU7 1XW

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Artus, Surroca Juan Jose Vilanova i la Geltrú , ES 3 4
Fernandez, Bleda David Castelldefels, ES 3 3
Iacoangeli, Tommaso Rome, IT 31 13
Lluis, Tous Jordi Tarragona, ES 3 3

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