Inhibitors of Akt activity
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United States of America Patent
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Mar 22, 2011
Grant Date -
Nov 20, 2008
app pub date -
Dec 9, 2005
filing date -
Dec 15, 2004
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Expired
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Abstract
The present invention is directed to compounds which contain substituted naphthyridines which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for treating cancer comprising administration of the compounds of the invention. These substituted naphthyridines have unexpected advantageous properties when compared to other naphthyridines reported in PCT publication WO2003/086394, such unexpected advantageous properties may include increased cellular potency/solubility, greater selectivity, enhanced pharmacokinetic properties, lack of off target activity and so on.
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