Method of extended culture for antigen-specific cytotoxic lymphocytes
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United States of America Patent
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Mar 22, 2011
Grant Date -
Feb 24, 2005
app pub date -
Aug 15, 2002
filing date -
Aug 15, 2001
priority date (Note) -
Expired
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Abstract
The present invention is a method for inducing cytotoxic T cell having an antigen-specific cytotoxic activity, a method for maintaining the cell, a method for continuously culturing the cell or a method for expanding the cell, comprising the step of culturing a cytotoxic T cell in the presence of at least one substance selected from the group consisting of (A) a substance having a binding activity to CD44; (B) a substance capable of regulating a signal emitted by binding a CD44 ligand to CD44; (C) a substance capable of inhibiting binding of a growth factor to a growth factor receptor; (D) a substance capable of regulating a signal emitted by binding of a growth factor to a growth factor receptor; and (E) fibronectin, a fragment thereof or a mixture thereof.
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