Methods of determining the level of human tumor necrosis factor receptor-like 2
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United States of America Patent
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Mar 22, 2011
Grant Date -
May 21, 2009
app pub date -
Sep 23, 2008
filing date -
Jun 5, 1995
priority date (Note) -
Expired
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Abstract
The present invention relates to novel members of the Tumor Necrosis Factor family of receptors. The invention provides isolated nucleic acid molecules encoding a human TR2 receptor and two splice variants thereof. TR2 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TR2 receptor activity. Also provided are diagnostic methods for detecting disease states related to the aberrant expression of TR2 receptors. Further provided are therapeutic methods for treating disease states related to aberrant proliferation and differentiation of cells which express the TR2 receptors.
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