MHC class II epitopes of 5T4 antigen
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United States of America Patent
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Mar 22, 2011
Grant Date -
Jun 2, 2005
app pub date -
Feb 13, 2003
filing date -
Feb 13, 2002
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Abstract
There is provided an MHC class II peptide epitope from 5T4 antigen. In particular, there is provided a peptide epitope of 5T4 which comprises one of the following: (i) the minimal epitope from the amino acid sequence shown as SEQ ID No. 2; (ii) the minimal epitope from the amino acid sequence shown as SEQ ID No. 3; (iii) a minimal epitope from the region 281-420 of 5T4. There is also provided a vaccine comprising such a peptide (or precursor thereof) and its use to treat and/or prevent a disease, in particular a cancerous disease.
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