Use of oligomers and polymers for drug solubilization, stabilization, and delivery
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United States of America Patent
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Mar 1, 2011
Grant Date -
Jun 18, 2009
app pub date -
Dec 18, 2008
filing date -
Dec 21, 2001
priority date (Note) -
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Abstract
The invention relates to the use of oligomers and polymers capable of rendering insoluble drugs soluble, protecting unstable drugs, and facilitating the delivery of drugs to their site of action. This invention further relates to processes for the preparation of such oligomers and polymers, and to compositions containing them. In some instances, oligomers, polymers, and/or mixtures thereof can be used to protect a protein drug. Such structures can include at least one recognition element covalently attached to a hydrophilic element, wherein said recognition element or elements interact noncovalently with the protein drug to form a complex in which said protein drug is protected from degradation, recognition by the immune system, and/or renal excretion.
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