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Abstract

It comprises a preparation process of delmopinol or a pharmaceutically acceptable salt and/or a solvate thereof, by submitting the compound of formula (II) where R.sub.1 and R.sub.2 are the same or different, independently selected from the group consisting of H, (C.sub.1-C.sub.6)-alkyl or, alternatively, R.sub.1 and R.sub.2 form, together with the carbon atom to which they are attached, a (C.sub.5-C.sub.6)-cycloalkyl radical; and R.sub.3 is a radical selected from the group consisting of CF.sub.3, (C.sub.1-C.sub.4)-alkyl, phenyl, and phenyl mono- or disubstituted by a radical selected from the group consisting of (C.sub.1-C.sub.4)-alkyl, halogen and nitro to a deprotection and cyclisation reaction. The process is useful to prepare delmopinol or its salts on an industrial scale. The compound of formula (II) is new and also forms part of the present invention, as well as its preparation process and other new intermediates of said preparation process. ##STR00001##

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First Claim