Process for the preparation of non-toxic anthrax vaccine
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United States of America Patent
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Feb 15, 2011
Grant Date -
Mar 24, 2005
app pub date -
Mar 20, 2002
filing date -
Dec 5, 2001
priority date (Note) -
Expired
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Abstract
. Protective antigen, PA is the main component of all the vaccines against anthrax. The protective efficacy of PA is greatly increased if small quantities of LF of EF are incorporated into the vaccines. An ideal vaccine against anthrax should contain PA, LF and EF together, but this combination would be toxic. Therefore, the biologically inactive mutant preparations of PA, LF and EF may be used together for better immunoprotection. The present invention describes the method for generation of recombinant vaccine against anthrax, comprising of non-toxic, mutant anthrax toxin proteins. The procedure involves site-directed mutagenesis of the native genes of the toxin proteins, the expression and purification of the mutant proteins and finally characterization of these proteins.
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