Synthetic agonists of TLR9
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United States of America Patent
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Feb 8, 2011
Grant Date -
Nov 27, 2008
app pub date -
Dec 12, 2007
filing date -
Dec 12, 2006
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Expired
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Abstract
The invention provides novel oligonucleotide-based compounds that individually provide distinct immune response profiles through their interactions as agonists with TLR9. The TLR9 agonists according to the invention are characterized by specific and unique chemical modifications, which provide their distinctive immune response activation profiles.
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