Use of C3a and derivatives thereof as a biomarker for colorectal adenoma and/or carcinoma; method for detection and test system
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United States of America Patent
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Feb 8, 2011
Grant Date -
Jul 3, 2008
app pub date -
Aug 11, 2005
filing date -
Aug 13, 2004
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Abstract
The present invention is directed to a method for detecting colorectal adenoma and/or colorectal carcinoma comprising the steps: a) providing an isolated sample material which has been taken from an individual, b) determining the level of C3a or a derivative thereof in said isolated sample material, c) comparing the determined level of C3a or a derivative thereof with one or more reference values. The invention is further directed to a method for discriminating between colorectal adenoma and colorectal carcinoma as well as to a method for monitoring the course of colorectal adenoma and/or colorectal carcinoma and/or the treatment of colorectal adenoma and/or colorectal carcinoma. Moreover, the invention is directed to a test system and an array for use in these methods. Furthermore, the invention is directed to the use of C3a as a biomarker for a detection of colorectal adenoma and/or colorectal carcinoma in an individual. Further, the invention is directed to method for determining whether a compound is effective in the treatment colorectal adenoma and/or colorectal carcinoma.
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