Method for designing surfaces
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United States of America Patent
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Feb 1, 2011
Grant Date -
May 3, 2007
app pub date -
Dec 10, 2004
filing date -
Dec 12, 2003
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Abstract
A method of producing a binding surface for a target molecule having a functional binding site, which method comprises: (i) identifying within the target molecule an anchor site which is remote from the functional binding site; (ii) generating a pharmacophore model for the anchor site; (iii) using the pharmacophore model to identify an anchor site binding ligand; and (iv) providing the anchor site binding ligand on a surface of a substrate such that the ability of the anchor site binding ligand to bind to the anchor site is preserved.
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