Method for the diagnosis and prognosis of demyelinating diseases
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United States of America Patent
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Feb 1, 2011
Grant Date -
Aug 21, 2008
app pub date -
May 22, 2006
filing date -
May 23, 2005
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Expired
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Abstract
The present invention refers to the use of glutamate transporters, glutamate and EGF to detect the presence of demyelinating diseases in a subject, to determine the status or severity of the same or to monitor the effects of a therapy administered to a subject who suffers from such diseases; to the use of the said markers for the searching, identification, development and evaluation of the efficacy of compounds for the treatment of such diseases, with a view to developing new drugs; to the use of compounds which promote the expression of the EAAT1 and EAAT2 transporters, as well as EGF for the treatment of demyelinating diseases. In a preferred embodiment, the methods and compounds of the invention are applicable to MS.
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