Fabrication of a high resolution biological molecule detection device
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United States of America Patent
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Feb 1, 2011
Grant Date -
Aug 25, 2005
app pub date -
Nov 19, 2002
filing date -
Nov 21, 2001
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Abstract
The present invention relates to a method of manufacturing a detection device which involves providing a substrate having a layer of electrically conductive material and a first layer of photosensitive material. Next, the substrate is subjected to a first level photolithography treatment to produce an electrical conductor containing conductive fingers with spaces between them. Finally, biological probes are attached to the conductive fingers under conditions effective to form a gap between the biological probes on the spaced apart conductive fingers, whereby a target molecule, if present in a sample, can bind to a pair of the biological probes on the spaced apart conductive fingers to bridge the gap between the biological probes, allowing detection of the target molecule.
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