Benzimidazole vascular damaging agents
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United States of America Patent
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Jan 25, 2011
Grant Date -
Nov 23, 2006
app pub date -
Jul 11, 2006
filing date -
Jan 15, 1999
priority date (Note) -
Expired
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Abstract
Vascular damaging agents composed of substituted 5(6)-substituted benzimidazole-2-carbamates are provided. These agents are useful in the preparation of medicaments for the treatment of diseases involving neovascularisation, particularly for the treatment of solid tumors, macular degeneration, diabetic retinopathy, rheumatoid arthritis, psoriasis, and atherosclerosis. Embodiments include a 5(6)-substituted benzimidazole-2-carbamate of formula Iwherein A represents a multi-substituted alkyl group or aromatic ring.
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