Process for producing biphosphonic acids and forms thereof
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United States of America Patent
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Jan 18, 2011
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app pub date -
Jun 13, 2005
filing date -
Jun 13, 2005
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Abstract
Disclosed herein is a process for producing bisphosphonic acids and salts thereof. The process comprising reacting a carboxylic acid of Formula [I] with phosphorous acid and halophosphorus compound in the presence of a solvent selected from aliphatic hydrocarbon or water miscible cyclic ether. Further, the present invention also provides novel forms of bisphosphonic acids and process for preparation thereof.
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