Methods involving PDE4, compositions, and the screening thereof, for the treatment of degenerative ocular pathologies
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United States of America Patent
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Jan 18, 2011
Grant Date -
Oct 26, 2006
app pub date -
Feb 18, 2004
filing date -
Feb 19, 2003
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Expired
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Abstract
The invention relates to the field of biology, genetics and medicine. In particular, the invention relates to novel methods for the detection, characterization and/or treatment (or management) of neurodegenerative pathologies. The invention also relates to methods for the identification or screening of compounds active in the aforementioned pathologies. The invention further relates to the compounds, genes, cells, plasmids or compositions which are used to carry out said methods. In particular, the invention is based on the identification of the role of phosphodiesterase 4B, the peripheral benzodiazepine receptor (PBR) and GABA receptors of the type GABA(A) in neurodegenerative pathologies and describes the use of same as therapeutic, diagnostic or experimental markers or targets for said disorders.
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