Recombinant bacterial vaccine system with environmentally limited viability

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United States of America Patent

PATENT NO 7871604
SERIAL NO

09120970

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Abstract

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vaccines by limiting their growth to the warmer environment inside the host. Such vaccines can be administered to protect humans or warm-blooded animals against bacterial, viral, mycotic and parasitic pathogens, especially those that colonize on or invade through mucosal surfaces. This antigen delivery system can also be used for expression of gamete-specific antigens to induce immune responses to block fertilization, or to induce immune responses to tumor antigens. In the event that an individual sheds live vaccine into the environment, the presence of the ELVS prevents survival of the vaccine. When environmentally regulated lethal genes are present on an extrachromosomal element and are regulated by chromosomal genes, transfer of the extrachromosomal element to other microorganisms will be limited by unregulated expression of the lethal genes in the recipient microorganism.

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Patent Owner(s)

Patent OwnerAddress
WASHINGTON UNIVERSITYONE BOOKINGS DRIVE ST LOUIS MO 63130

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Curtiss,, III Roy St. Louis, US 38 373
Tinge, Steven A Belleville, US 5 147

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