Processes for the synthesis of olanzapine
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United States of America Patent
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Jan 4, 2011
Grant Date -
Dec 25, 2008
app pub date -
Oct 30, 2007
filing date -
Jun 22, 2007
priority date (Note) -
Expired
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Abstract
There is provided a process for the preparation of olanzapine comprising: i) reacting 4-amino-2-methyl-10H-thieno-[2,3-b][1,5]benzodiazepine and N-methylpiperazine in a C.sub.1 to C.sub.4 alcoholic solvent or mixture thereof at suitable temperature and for a suitable time, ii) cooling the reaction mixture, and iii) isolating the precipitated olanzapine.
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