Induction of apoptosis by inhibition of sirtuin SIRT1 expression
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United States of America Patent
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Jan 4, 2011
Grant Date -
Aug 23, 2007
app pub date -
Feb 11, 2005
filing date -
Feb 11, 2004
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Expired
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Abstract
The invention relates to the induction of apoptosis by inhibition of the sirtuin SIRT1 expression, in particular the induction of apoptosis in tumour cells. Materials and methods for inhibiting SIRT1 expression are provided, including RNA interference methods. In particular, the invention provides a method of treating a proliferative disease comprising administering to an individual in need thereof an effective amount of a SIRT1 inhibitor.
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