Nanostructured surfaces as a dual ionization LDI-DESI platform for increased peptide coverage in proteomic analysis
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United States of America Patent
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Dec 28, 2010
Grant Date -
Apr 17, 2008
app pub date -
Sep 20, 2007
filing date -
Sep 20, 2006
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Abstract
Embodiments of the invention include methods and devices for the analysis of proteins utilizing a gold coated nanoporous alumina surface for dual ionization mode mass spectrometric analysis using desorption electrospray ionization (DESI) and laser desorption ionization (LDI). Combined use of DESI and LDI gives increased sequence coverage in peptide mixture analysis from a single sample preparation.
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