Process for isolation of desired isomers of nebivolol intermediates
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United States of America Patent
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Dec 28, 2010
Grant Date -
Mar 19, 2009
app pub date -
Jan 18, 2006
filing date -
Jan 18, 2006
priority date (Note) -
Expired
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Abstract
The present invention relates to a simple and commercially viable process for separation of desired isomers of nebivolol intermediates from a mixture containing undesired isomers of nebivolol intermediates. Thus, (+)-[2R*[1S*,5S*(S*)]]+[2R*[1S*,5R*(R*)]]-.alpha.,.alpha.'-[phenylmethyli-minobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol] is dissolved in diisopropyl ether at reflux temperature and cooled to below about 30.degree. C. to obtain the desired (+)-[2R*[1S*,5S*(S*)]]-.alpha.,.alpha.'-[phenylmethyliminobis(methylene)]-bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol].
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