Inhibitors of prolyl-hydroxylase-1 for the treatment of skeletal muscle degeneration
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United States of America Patent
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Dec 28, 2010
Grant Date -
Feb 19, 2009
app pub date -
Jul 11, 2008
filing date -
Jan 17, 2006
priority date (Note) -
Expired
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Abstract
The invention relates to the field of muscle pathologies, more particularly to the field of diseases where skeletal muscle degeneration occurs. The invention describes transgenic mice that do not produce prolyl-hydroxylase-1, -2 or -3. It is revealed that the phenotype of the prolyl-hydroxylase 1 knock-out mouse is characterized by a protection of skeletal muscle atrophy due to a variety of muscle damages, especially ischemic insults. The invention thus relates to the use of molecules that can bind to prolyl-hydroxylase-1 for the prevention and/or treatment of skeletal muscle degeneration.
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