Apparatus and method for determining the concentration of iodine-containing organic compounds in an aqueous solution
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United States of America Patent
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Dec 28, 2010
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Jun 3, 2008
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Jun 5, 2007
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Abstract
A method for determining the amount of a known iodine-containing organic compound in an aqueous solution. The method comprises electrochemically reducing the known iodine-containing organic compound in an aqueous medium to release iodide anions, chemically oxidizing the iodide anions to produce molecular iodine, and measuring the amount of molecular iodine. The known iodine-containing organic compound is preferably an aryl iodide, such as Iothalamate. Other preferred iodine-containing organic compounds include various glomerular filtration rate (GFR) marker compounds in plasma or urine samples, as useful in the measurement of GFR for an animal. The electrochemical reduction of the known iodine-containing organic compound is preferably performed in an electrochemical cell including a working electrode separated from a counter electrode by a cation exchange membrane. The working electrode most preferably includes bismuth and the counter electrode most preferably includes platinum.
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