Polynucleotides and methods of directing the ratio of B2:B1 avermectins in Streptomyces avermitilis host cells
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United States of America Patent
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Dec 28, 2010
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app pub date -
Jun 11, 2003
filing date -
Aug 12, 1999
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Abstract
The present invention relates to polynucleotide molecules comprising nucleotide sequences encoding an aveC gene product, which polynucleotide molecules can be used to alter the ratio or amount of class 2:1 avermectins produced in fermentation cultures of S. avermitilis. The present invention further relates to vectors, host cells, and mutant strains of S. avermitilis in which the aveC gene has been inactivated, or mutated so as to change the ratio or amount of class 2:1 avermectins produced.
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