Chemoprevention of endometrial cancer
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United States of America Patent
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Dec 28, 2010
Grant Date -
Sep 13, 2007
app pub date -
Jan 22, 2007
filing date -
Jan 27, 2006
priority date (Note) -
Expired
status (Latency Note)
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Abstract
The present invention is directed to intrauterine devices that release progestins or an inflammatory cytokine after placement. These devices can be used to reduce the risk of a woman developing endometrial cancer. The invention is also directed to therapeutic methods in which a sample of uterine cells obtained from a woman is assayed to determine the extent to which PTEN null clones (latent endometrial precancers) are present. In cases where the number of such null clones is high, the woman is administered an intrauterine device that releases either a progestin or an inflammatory cytokine.
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