System for detecting protease
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United States of America Patent
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Dec 21, 2010
Grant Date -
Nov 22, 2007
app pub date -
Aug 16, 2006
filing date -
Aug 10, 2001
priority date (Note) -
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Abstract
Disclosed is a system for detecting a protease inside a cell. In one embodiment, the system includes a chimeric protein that comprises as covalently linked components: 1) at least one optionally masked signal protein; 2) at least one protease-specific cleavage site; and 3) at least one detectable amino acid sequence. The invention has a wide spectrum of applications including use in the detection of novel protease inhibitors inside cells and tissue.
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