Bioinformatic method for identifying surface-anchored proteins from gram-positive bacteria and proteins obtained thereby
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United States of America Patent
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Dec 14, 2010
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app pub date -
Oct 8, 2009
filing date -
Sep 13, 2002
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Abstract
bacteria, and proteins and peptides obtained thereby are provided which can be utilized in methods to prevent and treat infections caused by Gram-positive bacteria. The method involves identifying from sequence information those proteins with a putative C-terminal LPXTG (SEQ ID NO:1) cell wall sorting signal and other structural similarities to MSCRAMM® proteins having the LPXTG-anchored cell wall proteins. The MSCRAMM® proteins and immunogenic regions therein that are identified and isolated using the present invention may be useful in the diagnosis, treatment or prevention of Gram positive bacterial infections.
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