Manipulation of cytokine levels using CD83 gene products
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United States of America Patent
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Dec 14, 2010
Grant Date -
Apr 1, 2010
app pub date -
Oct 2, 2009
filing date -
Nov 21, 2001
priority date (Note) -
Expired
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Abstract
The invention provides methods for modulating cytokine levels, GM-CSF levels and the immune system using CD83 nucleic acids, CD83 polypeptides, anti-CD83 antibodies and factors that influence CD83 activity or expression. The invention also provides mice having a mutant CD83 gene and mice having a transgenic CD83 gene, which are useful for defining the role of CD83 in the immune system and for identifying compounds that can modulate CD83 and the immune system.
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