)-one derivatives as calcium receptor antagonists
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United States of America Patent
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Nov 9, 2010
Grant Date -
Apr 10, 2008
app pub date -
Oct 4, 2007
filing date -
Oct 4, 2006
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Abstract
The present invention is directed to novel pyrido[4,3-d]pyrimidin-4(3H)-one derivatives and pharmaceutically acceptable salts thereof of structural formula Iare as described herein. Also provided are pharmaceutical compositions comprising the compounds of formula I as well as methods of treatment employing compounds of formula I to treat a disease or disorder characterized by abnormal bone or mineral homeostasis such as hypoparathyroidism, osteoporosis, osteopenia, periodontal disease, Paget's disease, bone fracture, osteoarthritis, rheumatoid arthritis, and humoral hypercalcemia of malignancy.
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