TNF antagonists
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United States of America Patent
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Oct 26, 2010
Grant Date -
Jun 18, 2009
app pub date -
Nov 21, 2005
filing date -
Nov 22, 2004
priority date (Note) -
Expired
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Abstract
TNF binding polypeptides based on human tetranectin C-type lectin like domains (CTLD) with improved binding characteristics and improved efficacy. The polypeptides comprise a TNF binding domain having the amino acid sequence KRWS-RYF (SEQ ID NO:1). Also provided are methods of preparing the polypeptides of the invention. The polypeptides may be used for the preparation of pharmaceutical compositions, and for treatment of a subject having a pathology mediated by TNF, such as treatment of rheumatoid arthritis.
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