Chimeric human growth hormone derived from the placenta and pituitary isoform and processes for obtaining said chimera
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United States of America Patent
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Oct 26, 2010
Grant Date -
Jun 7, 2007
app pub date -
Jun 23, 2004
filing date -
Jun 23, 2004
priority date (Note) -
Expired
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Abstract
A way to increase the production of recombinant polypeptides by combining pieces of several different isoforms of a given gene to make a chimeric isoform of the gene (using a chimeric gene can increase the production of polypeptide over 25%), or by inserting several copies of the coding region in tandem into a transformation vector (e.g., plasmids carrying multiple copies of the chimera of SEQ ID NO: 3 increased production 107%).
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